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<p>The grafted polymerization of <i>N</i>-vinylpyrrolidone onto collagen in the presence of tributylborane and a number of <i>p</i>-quinones (<i>p</i>-benzoquinone, <i>p</i>-naphthoquinone, 2,5-di-<i>tert</i>-butyl-<i>p</i>-benzoquinone, and duroquinone) was studied. The trialkylborane—<i>p</i>-quinone system allows one to form cross-linked copolymers due to a combination of two polymerization routes: “<i>grafting from</i>” and “<i>grafting to</i>.” Grafted poly-<i>N</i>-vinylpyrrolidone has high molecular weights and a high degree of polydispersity, which depend on the structure of the <i>p</i>-quinone used. An MTT assay of cytotoxicity shows that the copolymer extracts exhibit pronounced toxicity, which decreases when diluting with a growth medium to the appearance of the stimulating effect on the cell growth.</p>

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Alkylborane—p-quinone system in the synthesis of collagen and vinylpyrrolidone copolymers as a basis of materials for regenerative medicine

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • K. S. Gushchina,
  • Yu. L. Kuznetsova,
  • M. N. Egorikhina,
  • E. A. Levicheva,
  • L. L. Semenycheva

摘要

The grafted polymerization of N-vinylpyrrolidone onto collagen in the presence of tributylborane and a number of p-quinones (p-benzoquinone, p-naphthoquinone, 2,5-di-tert-butyl-p-benzoquinone, and duroquinone) was studied. The trialkylborane—p-quinone system allows one to form cross-linked copolymers due to a combination of two polymerization routes: “grafting from” and “grafting to.” Grafted poly-N-vinylpyrrolidone has high molecular weights and a high degree of polydispersity, which depend on the structure of the p-quinone used. An MTT assay of cytotoxicity shows that the copolymer extracts exhibit pronounced toxicity, which decreases when diluting with a growth medium to the appearance of the stimulating effect on the cell growth.