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<p>A series of new β-glucosides bearing pyridoxine-based aglycones and 4-methylbenzoyl moiety at the O(6) atom was synthesized. Cytotoxicity of the synthesized compounds was evaluated <i>in vitro</i> against four human tumor (MCF-7, HCT-116, PC-3, MDA-MB-231) and two human conditionally normal (Chang Liver, MSC) cell lines using camptothecin, doxorubicin, and saccharumoside-B as the reference drugs. The structure—antitumor activity relationships were established.</p>

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Synthesis and antitumor activity of β-glucosides bearing moieties of pyridoxine derivative and 4-methylbenzoic acid

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • M. V. Pugachev,
  • T. A. Khamzin,
  • I. I. Svintsova,
  • R. M. Khaziev,
  • M. N. Agafonova,
  • O. V. Bondar,
  • O. I. Gnezdilov,
  • Yu. G. Shtyrlin

摘要

A series of new β-glucosides bearing pyridoxine-based aglycones and 4-methylbenzoyl moiety at the O(6) atom was synthesized. Cytotoxicity of the synthesized compounds was evaluated in vitro against four human tumor (MCF-7, HCT-116, PC-3, MDA-MB-231) and two human conditionally normal (Chang Liver, MSC) cell lines using camptothecin, doxorubicin, and saccharumoside-B as the reference drugs. The structure—antitumor activity relationships were established.