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<p>The safety of α-, β-, and γ-cyclodextrin nitrates containing 1 to 3 nitrate groups was evaluated in connection with the possible use of these compounds as carriers of pharmacological substances. The α-, β-, and γ-cyclodextrin nitrates do not affect either iron-induced lipid peroxidation or calcium-induced mitochondrial depolarization and do not exhibit mitochondrial toxicity up to a concentration of 30 µmol L<sup>−1</sup>. They do not show microtubule-stabilizing activity and are capable of weakly suppressing the initial stages of tubulin polymerization. A low cytotoxicity (IC<sub>50</sub> &gt; 1 mmol L<sup>−1</sup>) of α-, β-, and γ-cyclodextrin derivatives against neuroblastoma cells was found. The set of biological assays indicates the absence of pronounced toxicity of the obtained α-, β-, and γ-cyclodextrin nitrates.</p>

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Chemical and biological properties of cyclodextrin nitrates as potential carriers of pharmacological substances

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • Yu. M. Mikhailov,
  • A. V. Maltsev,
  • S. O. Bachurin,
  • E. F. Shevtsova,
  • L. G. Dubova,
  • I. M. Veselov,
  • P. N. Shevtsov,
  • A. V. Darovskikh

摘要

The safety of α-, β-, and γ-cyclodextrin nitrates containing 1 to 3 nitrate groups was evaluated in connection with the possible use of these compounds as carriers of pharmacological substances. The α-, β-, and γ-cyclodextrin nitrates do not affect either iron-induced lipid peroxidation or calcium-induced mitochondrial depolarization and do not exhibit mitochondrial toxicity up to a concentration of 30 µmol L−1. They do not show microtubule-stabilizing activity and are capable of weakly suppressing the initial stages of tubulin polymerization. A low cytotoxicity (IC50 > 1 mmol L−1) of α-, β-, and γ-cyclodextrin derivatives against neuroblastoma cells was found. The set of biological assays indicates the absence of pronounced toxicity of the obtained α-, β-, and γ-cyclodextrin nitrates.