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<p>The sequential and combined sorption of bovine serum albumin (BSA) and copper ions on nanohydroxyapatite (HAP) changes the sorption capacity and sorption mechanism and affects the sorption reaction constants. Ligands, effectors of NO synthase <i>N</i>-(5,6-dihydro-4<i>H</i>-1,3-thiazin-2-yl)benzamide (iNOS inhibitor, L<sup>1</sup>) and <i>N</i>-(4-isopropylphenyl)-<i>N</i>-(1-imminoethyl)piperidine-1-carbothioamide hydrobromide (NOS activator, L<sup>2</sup>), are not sorbed on HAP. However, the CuL<sup>1</sup><sub>2</sub>Cl<sub>2</sub> complex shows weak binding to HAP possibly due to a higher sorption capacity of copper ions, which can displace calcium ions.</p>

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Sorption of copper and NO synthase effectors on hydroxyapatite and effect of bovine serum albumin on the sorption process

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • A. S. Zolotova,
  • T. P. Trofimova,
  • A. V. Severin,
  • M. A. Orlova

摘要

The sequential and combined sorption of bovine serum albumin (BSA) and copper ions on nanohydroxyapatite (HAP) changes the sorption capacity and sorption mechanism and affects the sorption reaction constants. Ligands, effectors of NO synthase N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (iNOS inhibitor, L1) and N-(4-isopropylphenyl)-N-(1-imminoethyl)piperidine-1-carbothioamide hydrobromide (NOS activator, L2), are not sorbed on HAP. However, the CuL12Cl2 complex shows weak binding to HAP possibly due to a higher sorption capacity of copper ions, which can displace calcium ions.