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<p>This review analyzed and discussed the data on the asymmetric addition of nucleophiles to 3,4-dihydroisoquinolines, their salts and <i>N</i>-oxides as an approach for synthesizing chiral 1,2,3,4-tetrahydroisoquinolines known as valuable pharmacological candidates.</p>

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Asymmetric addition to 3,4-dihydroisoquinolines

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • I. N. Egorov,
  • O. V. Pokharkar,
  • V. A. Platonov,
  • G. V. Zyryanov,
  • D. S. Kopchuk,
  • Ya. K. Shtaitz,
  • V. L. Rusinov

摘要

This review analyzed and discussed the data on the asymmetric addition of nucleophiles to 3,4-dihydroisoquinolines, their salts and N-oxides as an approach for synthesizing chiral 1,2,3,4-tetrahydroisoquinolines known as valuable pharmacological candidates.