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<p>A straightforward, eco-friendly, and sustainable methodology has been developed for the synthesis of 2,3-dihydroquinazoline scaffolds via cyclization of 2-aminobenzamide with aldehyde under Concentrated Solar Light Radiation (CSR). Remarkably, this approach eliminates the use of catalyst as well as solvent. The study highlights the viability of employing readily available and renewable concentrated solar light as a green energy source, facilitate the synthesis of 2,3-dihydroquinazoline derivatives with high to excellent (90–98%) yields. Beyond its operational simplicity, the method dispenses with tedious purification steps and demonstrates scalability up to gram quantities. Assessment of green chemistry metrics confirmed the environmental merits of the process, highlighting its reduced energy and alignment with the principles of atom economy and energy efficiency. Remarkably, this work highlights the transformative potential of CSR as a clean, accessible, and practical energy input for organic synthesis, particularly in the development of heterocyclic scaffolds of pharmaceutical importance.</p>

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Concentrated solar light-driven rapid and neat synthesis of quinazolines: a greener, sustainable, and an efficient approach

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Gobind Kumar,
  • Sarthak Sharma,
  • Archna,
  • Garima Sharma,
  • Gaurav Bhargava,
  • Jaspreet Kaur Rajput,
  • Baljinder Singh,
  • Rupesh Kumar

摘要

A straightforward, eco-friendly, and sustainable methodology has been developed for the synthesis of 2,3-dihydroquinazoline scaffolds via cyclization of 2-aminobenzamide with aldehyde under Concentrated Solar Light Radiation (CSR). Remarkably, this approach eliminates the use of catalyst as well as solvent. The study highlights the viability of employing readily available and renewable concentrated solar light as a green energy source, facilitate the synthesis of 2,3-dihydroquinazoline derivatives with high to excellent (90–98%) yields. Beyond its operational simplicity, the method dispenses with tedious purification steps and demonstrates scalability up to gram quantities. Assessment of green chemistry metrics confirmed the environmental merits of the process, highlighting its reduced energy and alignment with the principles of atom economy and energy efficiency. Remarkably, this work highlights the transformative potential of CSR as a clean, accessible, and practical energy input for organic synthesis, particularly in the development of heterocyclic scaffolds of pharmaceutical importance.