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<p>The synthesis of xanthene-1,8-dione and acridine-1,8-dione derivatives is of significant interest due to their potential applications in various fields, including pharmaceuticals and materials science. A simple, eco-friendly, and efficient green method has been developed for one-pot multicomponent synthesis of 1,8-dioxooctahydroxanthenes as an antiviral and antibacterial agents. A 1&#xa0;mol of an aldehyde and 2&#xa0;mol of dimedone reacts in a water-alcohol system, under reflux conditions resulting into xanthenediones. Microwave-assisted acridine-1,8-diones are synthesized using three components; aryl aldehydes, dimedone, and ammonium acetate in ethanol with excellent yields. The recyclable catalyst Xanthan Perchloric Acid (XPA) achieves high atom efficiency in a shorter time duration. The synthesized acridine and xanthene derivatives are characterized by spectroscopic methods. These innovative approaches reflect our efforts in optimizing the synthesis of acridine and xanthene derivatives, making the process more efficient, cost-effective, and environmentally benign using a reusable XPA catalyst. Future studies will focus on expanding the substrate scope, conducting mechanistic studies, and evaluating the biological activities of synthesized compounds.</p> Graphical Abstract <p></p>

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One-pot synthesis of 1,8-dioxo-decahydroacridines and 1,8-dioxo- octahydroxanthene derivatives using novel biopolymer xanthan perchloric acid (XPA) catalyst

  • 期刊论文

  • 发表日期：

    2026年2月15日

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  • Bhausaheb S. Narsale,
  • Dilip R. Thube,
  • Anil G. Gadhave,
  • Anil J. Dhole,
  • Sagar D. Mhaske,
  • Pravin N. Daule

摘要

The synthesis of xanthene-1,8-dione and acridine-1,8-dione derivatives is of significant interest due to their potential applications in various fields, including pharmaceuticals and materials science. A simple, eco-friendly, and efficient green method has been developed for one-pot multicomponent synthesis of 1,8-dioxooctahydroxanthenes as an antiviral and antibacterial agents. A 1 mol of an aldehyde and 2 mol of dimedone reacts in a water-alcohol system, under reflux conditions resulting into xanthenediones. Microwave-assisted acridine-1,8-diones are synthesized using three components; aryl aldehydes, dimedone, and ammonium acetate in ethanol with excellent yields. The recyclable catalyst Xanthan Perchloric Acid (XPA) achieves high atom efficiency in a shorter time duration. The synthesized acridine and xanthene derivatives are characterized by spectroscopic methods. These innovative approaches reflect our efforts in optimizing the synthesis of acridine and xanthene derivatives, making the process more efficient, cost-effective, and environmentally benign using a reusable XPA catalyst. Future studies will focus on expanding the substrate scope, conducting mechanistic studies, and evaluating the biological activities of synthesized compounds.

Graphical Abstract