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<p>This study highlights the design of a novel organo-nanocatalyst by grafting of thiourea onto dendritic fibrous nanosilica (DFNS). The resulting catalyst, named KCC-1-<i>nPr</i>-thiourea, was characterized using advanced techniques, such as FE-SEM, TEM, FT-IR, EDAX, mapping analysis. Also, pore size, pore volume and surface area of KCC-1-<i>nPr</i>-thiourea was determined by BET-BJH adsorption/desorption method which were 14.44 nm, 0.36 cm<sup>3</sup>/g and 100 m<sup>2</sup>/g, respectively. The analysis revealed that the catalyst exhibits uniform spherical morphologies with a fibrous dendritic structure. The fabricated nanocatalyst (KCC-1-<i>nPr</i>-thiourea) demonstrates outstanding performance due to its unique dendritic structure, which greatly enhances the accessibility of its active sites. KCC-1-<i>nPr</i>-thiourea as an advanced heterogeneous nanocatalyst, enhance the efficiency of 1,8-dioxo decahydroacridine synthesis through a one-pot, four-component reaction involving aromatic aldehydes, dimedone, and ammonium acetate, under solvent-free conditions. Its specialized structure optimizes the dispersion and adsorption of reactants and products within its pores and channels, contributing to its effectiveness in catalysis. This innovative approach dramatically reduces reaction times to just 10–20 min, yielding impressive product outputs of 93–98%, outperforming previously documented methods. With its multifunctional nature and environmentally friendly design, this organo-nanocatalyst offers a highly efficient and sustainable platform for producing diverse organic compounds. The porosity, high surface area and stability of silica nanoparticles as a support enhances the catalytic activity, recoverability and reusability of thiourea functional group.</p>

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KCC-1-nPr-thiourea as a novel mesoporous organo-nanocatalyst for the synthesis of 1,8-dioxo decahydroacridine derivatives: a new platform in pharmaceutical chemistry

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Habyl Naeemi,
  • Nasrin Shadjou,
  • Mehdi Mahmoudian

摘要

This study highlights the design of a novel organo-nanocatalyst by grafting of thiourea onto dendritic fibrous nanosilica (DFNS). The resulting catalyst, named KCC-1-nPr-thiourea, was characterized using advanced techniques, such as FE-SEM, TEM, FT-IR, EDAX, mapping analysis. Also, pore size, pore volume and surface area of KCC-1-nPr-thiourea was determined by BET-BJH adsorption/desorption method which were 14.44 nm, 0.36 cm3/g and 100 m2/g, respectively. The analysis revealed that the catalyst exhibits uniform spherical morphologies with a fibrous dendritic structure. The fabricated nanocatalyst (KCC-1-nPr-thiourea) demonstrates outstanding performance due to its unique dendritic structure, which greatly enhances the accessibility of its active sites. KCC-1-nPr-thiourea as an advanced heterogeneous nanocatalyst, enhance the efficiency of 1,8-dioxo decahydroacridine synthesis through a one-pot, four-component reaction involving aromatic aldehydes, dimedone, and ammonium acetate, under solvent-free conditions. Its specialized structure optimizes the dispersion and adsorption of reactants and products within its pores and channels, contributing to its effectiveness in catalysis. This innovative approach dramatically reduces reaction times to just 10–20 min, yielding impressive product outputs of 93–98%, outperforming previously documented methods. With its multifunctional nature and environmentally friendly design, this organo-nanocatalyst offers a highly efficient and sustainable platform for producing diverse organic compounds. The porosity, high surface area and stability of silica nanoparticles as a support enhances the catalytic activity, recoverability and reusability of thiourea functional group.