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<p>A mild and robust synthetic strategy has been developed for the synthesis of 1,3-thiazolidin-4-one derivatives via a one-pot, three-component reaction of aromatic or heteroaromatic aldehydes, aromatic amines, and thioglycolic acid under solvent-free conditions at 110&#xa0;°C. The reaction proceeds efficiently in the presence of iron oxide nanoparticles coated with hydroxyapatite (Fe<sub>3</sub>O<sub>4</sub>/HAP), serving as a heterogeneous solid-base nanocatalyst. This nanocatalyst produces good to excellent yields desired product and offers several practical advantages. Comprehensive characterization of the catalyst was performed using X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and field emission scanning electron microscopy. The new synthetic methodology has a shorter reaction time, a broad-substrate scope, and an eco-friendly and solvent-free approach. Due to its strong magnetic responsiveness, the catalyst can be conveniently recovered using an external magnetic field and reused for five successive cycles with negligible loss in activity.</p> Graphical abstract <p></p>

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An efficient and environmentally benign nanocatalytic approach for the one-pot, multicomponent synthesis of 1,3-thiazolidin-4-ones

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • Datta M. Gumatkar,
  • Shraddha V. Jadhav,
  • Navnath T. Hatvate,
  • Yatin U. Gadkari

摘要

A mild and robust synthetic strategy has been developed for the synthesis of 1,3-thiazolidin-4-one derivatives via a one-pot, three-component reaction of aromatic or heteroaromatic aldehydes, aromatic amines, and thioglycolic acid under solvent-free conditions at 110 °C. The reaction proceeds efficiently in the presence of iron oxide nanoparticles coated with hydroxyapatite (Fe3O4/HAP), serving as a heterogeneous solid-base nanocatalyst. This nanocatalyst produces good to excellent yields desired product and offers several practical advantages. Comprehensive characterization of the catalyst was performed using X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and field emission scanning electron microscopy. The new synthetic methodology has a shorter reaction time, a broad-substrate scope, and an eco-friendly and solvent-free approach. Due to its strong magnetic responsiveness, the catalyst can be conveniently recovered using an external magnetic field and reused for five successive cycles with negligible loss in activity.

Graphical abstract