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<p>This study outlines an easy, efficient and environmentally sustainable method for the green synthesis of manganese dioxide (MnO<sub>2</sub>) nanoparticles using an extract from <i>Psidium guajava</i> leaves. The catalytic activity of MnO<sub>2</sub>@Ag–S–CH<sub>2</sub>–COOH nanocatalyst was explored for the one-pot synthesis of hydrazinyl thiazole derivatives, utilizing a three-component reaction involving different aryl aldehydes, phenacyl bromides, and thiosemicarbazide. A number of techniques were used to characterize the MnO<sub>2</sub>@Ag–S–CH<sub>2</sub>–COOH nanocatalyst, field emission scanning electron microscopy (FE-SEM), Brunner–Emmett–Teller (BET), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS), and energy-dispersive X-ray (EDX). The structures of each newly synthesized derivative of hydrazinyl thiazole have been confirmed via the use of nuclear magnetic resonance (<sup>1</sup>H and <sup>13</sup>C NMR), fourier-transform infrared (FTIR) and high resolution mass spectrometry (HRMS). The&#xa0;MnO<sub>2</sub>@Ag–S–CH<sub>2</sub>–COOH nanocatalyst was readily extracted from the reactions with the use of an external magnet and could be reused five times without experiencing a substantial loss in efficacy. The synthesized compounds demonstrated promising results when assessed in vitro for their antimicrobial and anticancer activities. The anticancer efficacy of the synthesized hydrazinyl thiazole compounds were assessed in vitro against the MCF-7 human breast cancer cell line using the MTT assay. Among them, compounds 4a and 4e exhibited notable anticancer effects, with IC<sub>50</sub> values of 82.30 ± 0.58 and 84.25 ± 0.28&#xa0;μg/mL respectively.</p>

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Biosynthesis of MnO2 for MnO2@Ag–S–CH2–COOH: a novel catalyst for one-pot three-component synthesis of hydrazinyl thiazole derivatives, their anti-bacterial and anti-cancer study

  • 期刊论文

  • 发表日期：

    2025年10月24日

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  • Shankar P. Phulwale,
  • Avinash A. Survase,
  • Shivaji D. Waghmare,
  • Akshay P. Gurav,
  • Lalit D. Bhosale,
  • Madanrao M. Patil,
  • Dnyaneshwar S. Wankhede,
  • Krishna Chaitanya Gunturu,
  • Shankar P. Hangirgekar

摘要

This study outlines an easy, efficient and environmentally sustainable method for the green synthesis of manganese dioxide (MnO2) nanoparticles using an extract from Psidium guajava leaves. The catalytic activity of MnO2@Ag–S–CH2–COOH nanocatalyst was explored for the one-pot synthesis of hydrazinyl thiazole derivatives, utilizing a three-component reaction involving different aryl aldehydes, phenacyl bromides, and thiosemicarbazide. A number of techniques were used to characterize the MnO2@Ag–S–CH2–COOH nanocatalyst, field emission scanning electron microscopy (FE-SEM), Brunner–Emmett–Teller (BET), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS), and energy-dispersive X-ray (EDX). The structures of each newly synthesized derivative of hydrazinyl thiazole have been confirmed via the use of nuclear magnetic resonance (1H and 13C NMR), fourier-transform infrared (FTIR) and high resolution mass spectrometry (HRMS). The MnO2@Ag–S–CH2–COOH nanocatalyst was readily extracted from the reactions with the use of an external magnet and could be reused five times without experiencing a substantial loss in efficacy. The synthesized compounds demonstrated promising results when assessed in vitro for their antimicrobial and anticancer activities. The anticancer efficacy of the synthesized hydrazinyl thiazole compounds were assessed in vitro against the MCF-7 human breast cancer cell line using the MTT assay. Among them, compounds 4a and 4e exhibited notable anticancer effects, with IC50 values of 82.30 ± 0.58 and 84.25 ± 0.28 μg/mL respectively.