<p>The synthesis of 2,4,5-substituted imidazoles has garnered significant attention due to the diverse biological activities exhibited by these compounds. In this study, we report a novel approach utilizing copper ferrite-coated silica–titania nanocomposites, CuFe₂O₄@SiO₂.TiO₂, as an efficient catalyst for the one-pot synthesis of 2,4,5-substituted imidazoles. The reaction protocol involves the condensation of aryl aldehydes, benzil, and an ammonia source (ammonium acetate) under mild conditions. The synthesized nanocomposite catalyst demonstrates impressively high catalytic activity and selectivity, achieving good yields of the desired imidazole derivatives. Comprehensive characterization of the nanocomposites using techniques such as FT-IR, XRD, SEM, and TEM confirmed the successful synthesis and morphology of the catalyst. The catalyst’s effectiveness highlighted its recyclability and stability over six reaction cycles, making it a promising candidate for green synthetic methodologies. The optimized reaction conditions achieved excellent yields within a short reaction time and showcased the potential of this nanocomposite in facilitating green chemistry practices. This work highlights that the versatility of CuFe₂O₄@SiO₂.TiO₂ nanocomposites in organic synthesis opens new avenues for developing efficient catalytic systems to prepare biologically significant heterocycles, instilling hope for a more sustainable future in the field of chemistry.</p> Graphical Abstract <p></p>