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<p>A convenient four-component condensation reaction of phthalimide, hydrazine hydrate, malononitrile, and aromatic aldehyde has been executed by 3-picolinic acid in ethanol at reflux temperature in a very simple way. This developed method for synthesizing nitrilo-phthalazine derivatives is operationally simple, cost-effective, easy for product purification, environmentally benign, and high-yielding.</p> Graphical Abstract <p></p>

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A convenient metal-free one-pot synthesis of some phthalazine derivatives mediated by 3-picolinic acid

  • 期刊论文

  • 发表日期：

    2025年7月20日

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  • Izarul Islam,
  • Anamul Hossain,
  • Shormila R. Das,
  • Md. Mominuddin,
  • Pijush K. Roy,
  • Pran Gopal Karmaker,
  • Harendra N. Roy

摘要

A convenient four-component condensation reaction of phthalimide, hydrazine hydrate, malononitrile, and aromatic aldehyde has been executed by 3-picolinic acid in ethanol at reflux temperature in a very simple way. This developed method for synthesizing nitrilo-phthalazine derivatives is operationally simple, cost-effective, easy for product purification, environmentally benign, and high-yielding.

Graphical Abstract