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<p>The Golgi apparatus is one of the important organelles, and targeting imaging of Golgi apparatus is conducive to understanding the role of Golgi apparatus in diseases. Carbon quantum dots (CQDs) have attracted much attention in bioimaging because of their excellent fluorescence properties, good stability and superior biocompatibility. Based on the stereochemical structure transfer strategy, L-ascorbic acid (L-AA) with high reactivity and ethylenediamine were selected to synthesize L-CQDs by one-step hydrothermal method at low temperature and short time (100&#xa0;℃, 2&#xa0;h). L-CQDs has excitation dependence, high optical activity and low toxicity, and L-CQDs locates to the Golgi apparatus for imaging and Pearson correlation coefficient is 0.83.</p>

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Carbon quantum dots based on stereochemical structure transfer strategy for Golgi apparatus targeting imaging

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Yangyi Cao,
  • Lin Chen,
  • Xuguang Liu,
  • Rongrong Guo,
  • Yongzhen Yang,
  • Shiping Yu,
  • Yingying Wei

摘要

The Golgi apparatus is one of the important organelles, and targeting imaging of Golgi apparatus is conducive to understanding the role of Golgi apparatus in diseases. Carbon quantum dots (CQDs) have attracted much attention in bioimaging because of their excellent fluorescence properties, good stability and superior biocompatibility. Based on the stereochemical structure transfer strategy, L-ascorbic acid (L-AA) with high reactivity and ethylenediamine were selected to synthesize L-CQDs by one-step hydrothermal method at low temperature and short time (100 ℃, 2 h). L-CQDs has excitation dependence, high optical activity and low toxicity, and L-CQDs locates to the Golgi apparatus for imaging and Pearson correlation coefficient is 0.83.