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<p>The present research delineates the synthesis and catalytic assessment of a novel Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>–Pr–THAM–(OSO<sub>3</sub>H)<sub>3</sub> magnetic nanoparticles. The structural conformation of as-prepared Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>–Pr–THAM–(OSO<sub>3</sub>H)<sub>3</sub> nanoparticles was evaluated using numerous analytical methods like Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy, X-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis. The catalytic potential of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>–Pr–THAM–(OSO<sub>3</sub>H)<sub>3</sub> was tested for the syntheses of 4<i>H</i>-chromenes through one-pot condensation of 2-hydroxybenzaldehyde, cyclic 1,3-diketones, and 4-hydroxycoumarin in aqueous solution at 50&#xa0;°C. The current methodology offers the benefits of superior catalytic activity, the utilization of environmentally friendly solvents, easy work-up procedure, excellent yield, magnetic separation, shorter reaction times, and catalyst reusability with no significant loss in potency after six cycles. The synthesized 4<i>H</i>-chromene derivatives were screened for antibacterial and in vitro antioxidant study and were found to have promising activities supported by molecular docking studies.</p> Graphical abstract <p></p>

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Fe3O4@SiO2–Pr–THAM–(OSO3H)3: a novel magnetically separable catalyst for the synthesis of 4H-chromenes and their antioxidant and antibacterial study

  • 期刊论文

  • 发表日期：

    2025年1月26日

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  • Rutuja Ramesh Zond,
  • Arati Subhash Kulkarni,
  • Suvarna Raghunath Umape,
  • Padma Babulal Dandge,
  • Reshma Pandit Yadav,
  • Nitin Maruti Naik,
  • Vishal Hindurao Thorat,
  • Prafulla Balkrishna Choudhari,
  • Shankar Poshatti Hangirgekar,
  • Sandeep Ashok Sankpal

摘要

The present research delineates the synthesis and catalytic assessment of a novel Fe3O4@SiO2–Pr–THAM–(OSO3H)3 magnetic nanoparticles. The structural conformation of as-prepared Fe3O4@SiO2–Pr–THAM–(OSO3H)3 nanoparticles was evaluated using numerous analytical methods like Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy, X-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis. The catalytic potential of Fe3O4@SiO2–Pr–THAM–(OSO3H)3 was tested for the syntheses of 4H-chromenes through one-pot condensation of 2-hydroxybenzaldehyde, cyclic 1,3-diketones, and 4-hydroxycoumarin in aqueous solution at 50 °C. The current methodology offers the benefits of superior catalytic activity, the utilization of environmentally friendly solvents, easy work-up procedure, excellent yield, magnetic separation, shorter reaction times, and catalyst reusability with no significant loss in potency after six cycles. The synthesized 4H-chromene derivatives were screened for antibacterial and in vitro antioxidant study and were found to have promising activities supported by molecular docking studies.

Graphical abstract