<p>Predicting fish range shifts and assessing their vulnerability to climate change have garnered great interest in recent decades. Among the many marine fish that are vulnerable to climate change, sharks and their relatives (chondrichthyans) are of particular interest given their pivotal roles in marine ecosystems. Understanding intraspecific variations in the climatic niche of chondrichthyans is critical for accurately projecting their range shifts and assessing their vulnerability. In this review, we generalize the patterns and drivers of such intraspecific variations into a conceptual framework. We show that intraspecific variations in the fundamental/realized climatic niche of chondrichthyans can occur between populations, life-history stages, sexes, seasons, and over decades. These variations can be driven by various intrinsic factors (e.g., genetic/epigenetic changes, ontogenetic niche shifts, sexual segregation/dimorphisms, etc.) and external factors (e.g., differences in climatic conditions, anthropogenic stressors, and biotic interactions). Importantly, we advance the field by synthesizing emerging evidence on epigenetic (e.g., DNA methylation) and genetic (e.g., single nucleotide polymorphisms) mechanisms that underpin phenotypic plasticity and local adaptation in chondrichthyans. We identify key knowledge gaps, such as the need to incorporate less-studied climatic factors (e.g., salinity, dissolved oxygen, pH), and available data and methods. We also propose future research directions, including the integration of genomic, transcriptomic, and epigenomic data to unravel the molecular basis of niche variation. Our review contributes a comprehensive overview of the field and may guide future studies on intraspecific climatic-niche variations in chondrichthyans.</p>