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<p>This study aimed to investigate the regulatory mechanism of spinning solution composition on the structure and drug sustained-release behavior of inorganic–organic drug-loaded nanofiber membranes fabricated via emulsion electrospinning. By adjusting water content (0, 1, 1.5&#xa0;g) and zeolite loading, nanofiber membranes with different porous structures were prepared. Results indicated that fiber morphology and release kinetics were significantly influenced by the spinning solution composition: Systems containing water (W<sub>1</sub>-Zeo@DS NFs, W<sub>1.5</sub>-Zeo@DS NFs) formed shallow surface pores due to the emulsion template effect, resulting in finer fiber diameters. The system without water (Zeo@DS NFs) formed deeper internal channels via solvent-induced phase separation, leading to larger fiber diameters. Based on comprehensive release profiles and cumulative release rates, W<sub>1</sub>-Zeo@DS NFs demonstrated the optimal sustained-release performance and the highest drug utilization efficiency (56.85%). This study demonstrates that synergistic regulation of water content and zeolite loading can effectively optimize the multi-level pore structure of fibers, enabling precise control over drug release behavior, thereby providing a reference for designing efficient composite sustained-release drug delivery systems.</p>

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Construction of composite drug-loaded nanofiber membranes with tunable porous structure and study of their sustained release mechanism

  • 期刊论文

  • 发表日期：

    2026年5月28日

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  • Junlang Li,
  • Shaofeng Yin,
  • Lixin Chen,
  • Lei Chen,
  • Yang Chen,
  • TianTian Xie,
  • Yingjie Wang,
  • Xiaoting Deng

摘要

This study aimed to investigate the regulatory mechanism of spinning solution composition on the structure and drug sustained-release behavior of inorganic–organic drug-loaded nanofiber membranes fabricated via emulsion electrospinning. By adjusting water content (0, 1, 1.5 g) and zeolite loading, nanofiber membranes with different porous structures were prepared. Results indicated that fiber morphology and release kinetics were significantly influenced by the spinning solution composition: Systems containing water (W1-Zeo@DS NFs, W1.5-Zeo@DS NFs) formed shallow surface pores due to the emulsion template effect, resulting in finer fiber diameters. The system without water (Zeo@DS NFs) formed deeper internal channels via solvent-induced phase separation, leading to larger fiber diameters. Based on comprehensive release profiles and cumulative release rates, W1-Zeo@DS NFs demonstrated the optimal sustained-release performance and the highest drug utilization efficiency (56.85%). This study demonstrates that synergistic regulation of water content and zeolite loading can effectively optimize the multi-level pore structure of fibers, enabling precise control over drug release behavior, thereby providing a reference for designing efficient composite sustained-release drug delivery systems.