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<p>Spectrophotometric kinetic methods of the determination of absorption capacity in relation to oxygen-centered radicals and to 2,2′-diphenyl picrylhydrazyl stable radical was used to detect antiperoxyradical ability of folates: folic acid (FA) and its structural derivatives: 7,8-dihydrofolate (DHF), 5,6,7,8-tetrahydrofolate (THF), and 5-formyltetrahydrofolate (5-FTHF). It is established that reduced forms of folic acid—DHF and THF, possess significantly higher antiradical ability in comparison with FA and 5-FTHF. Square wave voltammetry method was used to determine redox characteristics of folates. The reaction sites of folates responsible for their antiradical activities were identified, and the most favorable one was discovered.</p> Graphical abstract <p></p>

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Kinetic determination of antiradical ability of folic acid and its structural derivatives

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Zaruhi H. Manukyan,
  • Samvel Kh. Stepanyan,
  • Makich V. Musayelyan,
  • Gaspar G. Kocharyan

摘要

Spectrophotometric kinetic methods of the determination of absorption capacity in relation to oxygen-centered radicals and to 2,2′-diphenyl picrylhydrazyl stable radical was used to detect antiperoxyradical ability of folates: folic acid (FA) and its structural derivatives: 7,8-dihydrofolate (DHF), 5,6,7,8-tetrahydrofolate (THF), and 5-formyltetrahydrofolate (5-FTHF). It is established that reduced forms of folic acid—DHF and THF, possess significantly higher antiradical ability in comparison with FA and 5-FTHF. Square wave voltammetry method was used to determine redox characteristics of folates. The reaction sites of folates responsible for their antiradical activities were identified, and the most favorable one was discovered.

Graphical abstract