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Purpose <p>Faced with scarcity of large-scale health measurement study in China, the study aims to provide health outcomes evidence from ischemic stroke patients.</p> Methods <p>Data were collected from a prospective multi-center real-world study held from March 2015 to December 2018. Health-related quality of life (HRQoL) was assessed at admission, hospital discharge, 90 ± 14&#xa0;days after medication treatment, and 360 ± 28&#xa0;days after medication treatment. Baseline characteristics of patients were summarized. Mean values and standard deviation (SD) of EQ-5D utility index scores, VAS values, and NIHSS scores were reported. Rank-sum test was applied to analyze the differences of HRQoL among patient groups. Mix-effects regression was used to investigate the impact factors.</p> Results <p>At the baseline visit, a total of 9978 patients with a mean age of 64.0&#xa0;years were included. The mean utility index scores recorded at admission, discharge, 90 ± 14 days after therapy initiated, and 360 ± 28&#xa0;days after therapy initiated were 0.546 (SD = 0.327), 0.709 (SD = 0.306), 0.801 (SD = 0.259), and 0.846 (SD = 0.237), respectively. Differences among sex and TOAST classification subgroups were observed. The mean utility index scores stratified by mRS levels ranged from 0.983 (SD = 0.076) to 0.058 (SD = 0.167) for level 0 to level 5. The mean NIHSS scores were 5.3 (SD = 4.98) and 3.6 (SD = 4.24) at admission and discharge.</p> Conclusion <p>The impact of ischemic stroke on patient’s HRQoL is significant, particularly during the acute phase. Results from the study are well representative and can be utilized in health policy making, economic evaluations and other comparison studies.</p> <p>The study was registered with ClinicalTrials.gov (NCT02470624) in October 2015.</p>

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Measuring the health outcomes of Chinese ischemic stroke patients based on the data from a longitudinal multi-center study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月27日

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  • Luying Wang,
  • Xin Guan,
  • Jiting Zhou,
  • Hongfei Hu,
  • Wei Liu,
  • Qiran Wei,
  • Yining Huang,
  • Weiping Sun,
  • Xuejing Jin,
  • Hongchao Li

摘要

Purpose

Faced with scarcity of large-scale health measurement study in China, the study aims to provide health outcomes evidence from ischemic stroke patients.

Methods

Data were collected from a prospective multi-center real-world study held from March 2015 to December 2018. Health-related quality of life (HRQoL) was assessed at admission, hospital discharge, 90 ± 14 days after medication treatment, and 360 ± 28 days after medication treatment. Baseline characteristics of patients were summarized. Mean values and standard deviation (SD) of EQ-5D utility index scores, VAS values, and NIHSS scores were reported. Rank-sum test was applied to analyze the differences of HRQoL among patient groups. Mix-effects regression was used to investigate the impact factors.

Results

At the baseline visit, a total of 9978 patients with a mean age of 64.0 years were included. The mean utility index scores recorded at admission, discharge, 90 ± 14 days after therapy initiated, and 360 ± 28 days after therapy initiated were 0.546 (SD = 0.327), 0.709 (SD = 0.306), 0.801 (SD = 0.259), and 0.846 (SD = 0.237), respectively. Differences among sex and TOAST classification subgroups were observed. The mean utility index scores stratified by mRS levels ranged from 0.983 (SD = 0.076) to 0.058 (SD = 0.167) for level 0 to level 5. The mean NIHSS scores were 5.3 (SD = 4.98) and 3.6 (SD = 4.24) at admission and discharge.

Conclusion

The impact of ischemic stroke on patient’s HRQoL is significant, particularly during the acute phase. Results from the study are well representative and can be utilized in health policy making, economic evaluations and other comparison studies.

The study was registered with ClinicalTrials.gov (NCT02470624) in October 2015.