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Purpose <p>To investigate whether surgery is more effective than follow-up in reducing psychological distress for patients with observable indeterminate pulmonary nodules (IPNs) and to assess if psychological distress can serve as a potential surgical indication for IPNs.</p> Methods <p>This prospective observational study included 341 patients with abnormal psychometric results, as measured by the Hospital Anxiety and Depression Scale (HADS). Of these, 262 patients opted for follow-up and 79 chose surgery. Initial psychological assessments (HADS1) were conducted at enrollment following nodule detection, with a second assessment (HADS2) one year later. A comparative analysis of dynamic psychological changes (ΔHADS: HADS2—HADS1) between the follow-up and surgical groups was performed.</p> Results <p>Both groups showed reductions in HADS-A [−&#xa0;3 (IQR, −&#xa0;7 to −&#xa0;1) for follow-up and − 3 (IQR, − 6 to − 1) for surgery] and HADS-D scores [− 2 (IQR, − 4 to 0) for follow-up and − 3 (IQR, − 7 to 0) for surgery]. Univariate analysis revealed that the surgical group had a significantly greater reduction in HADS-D scores compared to the follow-up group (Z = − 2.08, P = 0.037), but there were no significant differences in the changes in HADS-A scores between the groups (Z = − 1.04, P = 0.300). However, in multivariable analysis, surgery did not significantly improve the alleviation of depressive symptoms compared to follow-up (β = − 0.72, 95% CI: − 1.57 to 0.14, P = 0.101). Within the surgical group, female patients reported less relief from anxiety than male patients (Z = − 2.32, P = 0.021), and symptomatic patients experienced less relief from both anxiety (Z = − 2.14, P = 0.032) and depression (Z = − 3.01, P = 0.003).</p> Conclusions <p>Surgery does not provide additional psychological benefits over follow-up. This study does not support using psychological distress as a criterion for surgical intervention in IPNs from a psychological perspective.</p> <p><b>Trial registry</b> ClinicalTrials.gov (NCT04857333).</p>

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Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study

  • 期刊论文

  • 发表日期：

    2025年1月15日

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  • Junhan Wu,
  • Weitao Zhuang,
  • Rixin Chen,
  • Haijie Xu,
  • Zijie Li,
  • Zihua Lan,
  • Xin Xia,
  • Zhe He,
  • Shaopeng Li,
  • Cheng Deng,
  • Wei Xu,
  • Qiuling Shi,
  • Yong Tang,
  • Guibin Qiao

摘要

Purpose

To investigate whether surgery is more effective than follow-up in reducing psychological distress for patients with observable indeterminate pulmonary nodules (IPNs) and to assess if psychological distress can serve as a potential surgical indication for IPNs.

Methods

This prospective observational study included 341 patients with abnormal psychometric results, as measured by the Hospital Anxiety and Depression Scale (HADS). Of these, 262 patients opted for follow-up and 79 chose surgery. Initial psychological assessments (HADS1) were conducted at enrollment following nodule detection, with a second assessment (HADS2) one year later. A comparative analysis of dynamic psychological changes (ΔHADS: HADS2—HADS1) between the follow-up and surgical groups was performed.

Results

Both groups showed reductions in HADS-A [− 3 (IQR, − 7 to − 1) for follow-up and − 3 (IQR, − 6 to − 1) for surgery] and HADS-D scores [− 2 (IQR, − 4 to 0) for follow-up and − 3 (IQR, − 7 to 0) for surgery]. Univariate analysis revealed that the surgical group had a significantly greater reduction in HADS-D scores compared to the follow-up group (Z = − 2.08, P = 0.037), but there were no significant differences in the changes in HADS-A scores between the groups (Z = − 1.04, P = 0.300). However, in multivariable analysis, surgery did not significantly improve the alleviation of depressive symptoms compared to follow-up (β = − 0.72, 95% CI: − 1.57 to 0.14, P = 0.101). Within the surgical group, female patients reported less relief from anxiety than male patients (Z = − 2.32, P = 0.021), and symptomatic patients experienced less relief from both anxiety (Z = − 2.14, P = 0.032) and depression (Z = − 3.01, P = 0.003).

Conclusions

Surgery does not provide additional psychological benefits over follow-up. This study does not support using psychological distress as a criterion for surgical intervention in IPNs from a psychological perspective.

Trial registry ClinicalTrials.gov (NCT04857333).