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<p>Cognitive reserve (CR) refers to “the adaptation that helps to explain differential susceptibility of cognitive abilities or day-to-day function to brain aging, pathology, or insult”. Originally intended to explain individual differences observed in the context of cognitive aging, recent evidence from a handful of studies has shown that CR is also a protective factor for mental health. This study explored the relationship between CR and some measures of mental health in cross-sectional sample. Another aim of this study was to investigate whether CR might moderate the relationship between negative life events and mental health. CR (measured by education level, occupation attainment, and lifetime leisure activities), negative life events, and positive/negative mental health were assessed using a large survey with a sample of <i>N</i> = 15,953 Japanese adults (20–69 years). The results indicated that after adjusting for sociodemographic variables, there was an expected association between CR and mental health; however, the magnitude and significance differed by the mental health indicator or subgroups of age and sex. Furthermore, although limited, CR was found to mitigate the adverse effects of negative life events on mental health. Taken together, these findings suggest that CR may serve as a predictor of mental health outcomes across the lifespan, whereas such relationships can be altered by the lifestyle and experiences of people receiving the benefit of building CR. Future studies should investigate the mechanisms through which CR contribute to the improvement or maintenance of mental health.</p>

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The Contribution of Cognitive Reserve to Mental Health Against Adversarial Life Events in a Large Cross-Sectional Sample of Japanese People

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • Yuta Takiguchi,
  • Mie Matsui,
  • Daisuke Watanabe,
  • Junya Tsutsui

摘要

Cognitive reserve (CR) refers to “the adaptation that helps to explain differential susceptibility of cognitive abilities or day-to-day function to brain aging, pathology, or insult”. Originally intended to explain individual differences observed in the context of cognitive aging, recent evidence from a handful of studies has shown that CR is also a protective factor for mental health. This study explored the relationship between CR and some measures of mental health in cross-sectional sample. Another aim of this study was to investigate whether CR might moderate the relationship between negative life events and mental health. CR (measured by education level, occupation attainment, and lifetime leisure activities), negative life events, and positive/negative mental health were assessed using a large survey with a sample of N = 15,953 Japanese adults (20–69 years). The results indicated that after adjusting for sociodemographic variables, there was an expected association between CR and mental health; however, the magnitude and significance differed by the mental health indicator or subgroups of age and sex. Furthermore, although limited, CR was found to mitigate the adverse effects of negative life events on mental health. Taken together, these findings suggest that CR may serve as a predictor of mental health outcomes across the lifespan, whereas such relationships can be altered by the lifestyle and experiences of people receiving the benefit of building CR. Future studies should investigate the mechanisms through which CR contribute to the improvement or maintenance of mental health.