<p>We investigate the realization of a myriad of general local and nonlocal inhomogeneous elliptic and parabolic boundary value problems over classes of irregular regions. We present a unified approach in which either local or nonlocal Neumann, Robin, and Wentzell boundary value problems are treated simultaneously. We establish solvability and global regularity results for both the stationary and time-dependent heat equations governed by general differential operators with unbounded measurable coefficients and various boundary conditions at once, first on a general framework, and then by presenting concrete important examples of irregular domains, Wentzell-type boundary conditions, and nonlocal maps. As a consequence, we develop a priori estimates for multiple differential equations under various situations, which are tied to a large number of applications performed over real world regions, such heat transfer, electrical conductivity, stable-like processes (probability theory), diffusion of medical sprays in the bronchial trees, and oceanography (among many others).</p>