Scholarlink

Purpose <p>To investigate the prevalence and risk factors of vertebral fractures (VFs) and to compare bone mineral density (BMD) assessments by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in patients with acromegaly.</p> Methods <p>This cross-sectional study included 149 patients with acromegaly. Clinical, biochemical, and imaging data were collected, and logistic regression analyses were performed to identify VF risk factors.</p> Results <p>VFs were detected in 39.6% of patients and were associated with older age, longer disease duration, higher body mass index(BMI), elevated IGF-1 levels, and lower serum phosphorus. QCT-derived volumetric BMD (vBMD) was significantly lower in patients with VFs, whereas DXA-based lumbar areal BMD (aBMD) did not differ between groups. Elevated IGF-1 (%ULN) and reduced vBMD were identified as independent risk factors for VFs.</p> Conclusion <p>Vertebral fractures are common in acromegaly. In one of the largest Chinese acromegaly cohorts to date, QCT demonstrated superior discrimination of VF risk compared with DXA, supporting its potential complementary role in skeletal fragility assessment in acromegaly.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between vertebral fracture risk and bone mineral density in patients with acromegaly

  • 期刊论文

  • 发表日期：

    2025年12月9日

查看全文
  • Shuaiming Chen,
  • Min Liu,
  • Huiwen Tan,
  • Lin Ji,
  • Yerong Yu,
  • Shu Jiang,
  • Bowen Cai,
  • Wei Wang,
  • Songping Zheng,
  • Xin Zan,
  • Huan Xu,
  • Jing Li,
  • Jianwei Li

摘要

Purpose

To investigate the prevalence and risk factors of vertebral fractures (VFs) and to compare bone mineral density (BMD) assessments by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in patients with acromegaly.

Methods

This cross-sectional study included 149 patients with acromegaly. Clinical, biochemical, and imaging data were collected, and logistic regression analyses were performed to identify VF risk factors.

Results

VFs were detected in 39.6% of patients and were associated with older age, longer disease duration, higher body mass index(BMI), elevated IGF-1 levels, and lower serum phosphorus. QCT-derived volumetric BMD (vBMD) was significantly lower in patients with VFs, whereas DXA-based lumbar areal BMD (aBMD) did not differ between groups. Elevated IGF-1 (%ULN) and reduced vBMD were identified as independent risk factors for VFs.

Conclusion

Vertebral fractures are common in acromegaly. In one of the largest Chinese acromegaly cohorts to date, QCT demonstrated superior discrimination of VF risk compared with DXA, supporting its potential complementary role in skeletal fragility assessment in acromegaly.