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<p>Plant-derived terpenoids constitute one of the most structurally diverse and biologically active classes of natural products, offering substantial potential for therapeutic and industrial applications. This review provides a comprehensive synthesis of current advances in plant derived terpenoid medicines, beginning with the fundamental principles of terpene chemistry and extending to the complexity of plant specific biosynthetic pathways. We critically examine the therapeutic roles of terpenoids, with particular emphasis on their antioxidant, anticancer, antiallergic, and antimicrobial activities. Furthermore, the review highlights recent developments in biotechnological approaches, including genetic transformation, CRISPR genome editing, microRNA (miRNA) mediated regulation, and plant tissue culture, aimed at enhancing terpenoid biosynthesis and yield. Emerging chemical and green synthesis strategies are also discussed as sustainable alternatives to conventional plant extraction. By integrating perspectives from pharmacology, plant molecular biology, and synthetic chemistry, this review underscores the versatility of plant derived terpenoids as promising candidates for drug discovery and industrial innovation, while identifying key challenges and outlining future research directions.</p> Graphical abstract <p></p>

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Progress in plant-derived terpenoid: biosynthetic pathways, therapeutic roles, and sustainable production strategies

  • 期刊论文

  • 发表日期：

    2026年7月14日

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  • Abdul Fatah A. Samad,
  • Nazrin Abd-Aziz,
  • Joazaizulfazli Jamalis,
  • Mohd Bakri Bakar,
  • Azman Abd Samad,
  • Raihana Ridzuan,
  • Siti Ernieyanti Hashim,
  • Alina Wagiran,
  • Mira Panadi,
  • Mohd Ridzuan Mohd Abd Razak

摘要

Plant-derived terpenoids constitute one of the most structurally diverse and biologically active classes of natural products, offering substantial potential for therapeutic and industrial applications. This review provides a comprehensive synthesis of current advances in plant derived terpenoid medicines, beginning with the fundamental principles of terpene chemistry and extending to the complexity of plant specific biosynthetic pathways. We critically examine the therapeutic roles of terpenoids, with particular emphasis on their antioxidant, anticancer, antiallergic, and antimicrobial activities. Furthermore, the review highlights recent developments in biotechnological approaches, including genetic transformation, CRISPR genome editing, microRNA (miRNA) mediated regulation, and plant tissue culture, aimed at enhancing terpenoid biosynthesis and yield. Emerging chemical and green synthesis strategies are also discussed as sustainable alternatives to conventional plant extraction. By integrating perspectives from pharmacology, plant molecular biology, and synthetic chemistry, this review underscores the versatility of plant derived terpenoids as promising candidates for drug discovery and industrial innovation, while identifying key challenges and outlining future research directions.

Graphical abstract