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<p>Tight junctions (TJs), a critical regulator of intestinal barrier integrity, has gained increasing attention on fields like intestinal health and drug absorption. Recent researches highlighted the remarkable potential of natural plants on intestinal TJs through multiple mechanisms. This review selected several represented active components derived from natural medicinal plants (like flavonoids, saponins, alkaloids, and etc.) and formulas of traditional Chinese medicine (TCM), and systematically reviewed their mechanisms on modulating intestinal TJs, including the modulation of inflammatory responses, upregulation of tight junction proteins (TJPs) expression and promotion of intestinal epithelial cell repair. Furthermore, their potential applications in fields like management of intestinal disorders management and oral absorption are discussed. This review could provide novel perspectives and theoretical support on intestinal TJs related researches.</p> Graphical abstract <p></p>

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Mechanisms of action of natural plant-derived bioactive compounds in treating intestinal tight junctions dysfunction

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Jiduo Han,
  • Ziliang Xiao,
  • Lingyu Yang,
  • Jianfang Feng,
  • Yi Jin,
  • Meng Cheng,
  • Liangxing Tu

摘要

Tight junctions (TJs), a critical regulator of intestinal barrier integrity, has gained increasing attention on fields like intestinal health and drug absorption. Recent researches highlighted the remarkable potential of natural plants on intestinal TJs through multiple mechanisms. This review selected several represented active components derived from natural medicinal plants (like flavonoids, saponins, alkaloids, and etc.) and formulas of traditional Chinese medicine (TCM), and systematically reviewed their mechanisms on modulating intestinal TJs, including the modulation of inflammatory responses, upregulation of tight junction proteins (TJPs) expression and promotion of intestinal epithelial cell repair. Furthermore, their potential applications in fields like management of intestinal disorders management and oral absorption are discussed. This review could provide novel perspectives and theoretical support on intestinal TJs related researches.

Graphical abstract