<p>Flavonoids constitute a substantial category of polyphenolic compounds derived from plants, certain food constituents, and food supplements. They have garnered significant attention for their potential roles during pandemics. These natural products have a long history of use in folk medicine and exhibit a diverse array of bioactivities, including antimicrobial, antiviral, antioxidant, and anti-inflammatory properties. Recent studies indicate that they play a crucial role in combating viral infections such as SARS-CoV-2 by inhibiting viral replication and modulating immune system responses. Flavonoids enhance the host’s immune system while simultaneously reducing inflammation and oxidative stress, which are exacerbated during pandemics. Their capacity to regulate coagulation pathways and safeguard cardiac function renders them increasingly promising as a therapeutic intervention for complications arising from viral infections. Nanotechnology enhances the absorption and targeted delivery of flavonoids, potentially increasing their efficacy in clinical applications. Ongoing research suggests that the numerous advantages of flavonoids may play a crucial role in developing integrative treatment strategies, rendering them highly beneficial for public health, particularly during pandemics. This review emphasizes the necessity for further investigation into the functions and mechanisms of flavonoids and advocates for their incorporation in future preventive and therapeutic strategies.</p> Graphical abstract <p></p>