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<p>G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors, regulating immune response, neurotransmission, and hormonal activity. They play a crucial role in several diseases, including chronic kidney disease, rheumatoid arthritis, tuberculosis, malaria, and cholera. This review comprehensively examines GPCR signaling pathways and their implications in disease pathogenesis. Additionally, we explore the therapeutic potential of natural product inhibitors that modulate GPCR activity. Bioactive compounds from dietary sources exhibit promising pharmacological effects, emphasizing the interplay between nutrition and health. Their ability to regulate GPCR pathways provides new prospects for drug discovery and precision medicine. A systematic literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies published in the last two decades. Keywords such as “GPCR signaling,” “natural inhibitors of GPCRs,” “nutraceuticals and GPCR modulation,” and “GPCRs in disease” were used. Articles were selected based on relevance, methodological rigor, and contribution to GPCR biology. Eventually, 105 references were included. By synthesizing current findings, this review highlights the necessity of further research on GPCR biology to develop innovative therapeutic strategies. Nutraceutical regulation of GPCRs offers a promising avenue for improving treatment outcomes in neurological, cardiovascular, and endocrine disorders. Understanding these mechanisms could significantly advance pharmacological interventions, paving the way for novel therapeutic applications.</p>

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Nutraceutical regulations of G-protein coupled receptors in neurological, cardiovascular and endocrine disorders: a review

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Bayo Olufunso Adeoye,
  • Oyedayo Phillips Akano,
  • Demilade Remilekun Awojebe,
  • Babafemi Tosin Ogunbiyi,
  • Ayodeji David Adeoye,
  • Ngozi Angela Ukangwa,
  • Elizabeth Omobude-Aisagbonhi,
  • Oludayo Adeyemi Olosunde,
  • Adedayo Hakeem Oyebanji

摘要

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors, regulating immune response, neurotransmission, and hormonal activity. They play a crucial role in several diseases, including chronic kidney disease, rheumatoid arthritis, tuberculosis, malaria, and cholera. This review comprehensively examines GPCR signaling pathways and their implications in disease pathogenesis. Additionally, we explore the therapeutic potential of natural product inhibitors that modulate GPCR activity. Bioactive compounds from dietary sources exhibit promising pharmacological effects, emphasizing the interplay between nutrition and health. Their ability to regulate GPCR pathways provides new prospects for drug discovery and precision medicine. A systematic literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies published in the last two decades. Keywords such as “GPCR signaling,” “natural inhibitors of GPCRs,” “nutraceuticals and GPCR modulation,” and “GPCRs in disease” were used. Articles were selected based on relevance, methodological rigor, and contribution to GPCR biology. Eventually, 105 references were included. By synthesizing current findings, this review highlights the necessity of further research on GPCR biology to develop innovative therapeutic strategies. Nutraceutical regulation of GPCRs offers a promising avenue for improving treatment outcomes in neurological, cardiovascular, and endocrine disorders. Understanding these mechanisms could significantly advance pharmacological interventions, paving the way for novel therapeutic applications.