<p>Clinical supervision is a critical enabler of advanced pharmacist practice. Despite this, within the United Kingdom, it remains poorly developed and inconsistently applied across the profession. Existing supervisory frameworks in pharmacy are historically rooted in compliance and public protection rather than professional development, and the proliferation of supervision terminology across sectors has created conceptual fragmentation that undermines consistent practice. This paper proposes a domain-based taxonomy of supervision – spanning clinical, management, educational and academic domains, with pastoral supervision as their connective core – anchored to the four-pillar structure underpinning advanced practice in the United Kingdom. Within this taxonomy, a conceptual model is presented comprising five core clinical supervisory approaches: preceptorship, needs-based supervision, incidental supervision, peer review and assurance supervision. These are not sequential or mandatory stages, but flexible developmental tools, informed by Benner’s novice-to-expert continuum, selected in response to assessed need and baseline capability rather than assumed career seniority. An illustrative hospital pharmacist example demonstrates how the model operates in practice, with supervisory approaches layered and sequenced to support safe progression from initial role transition through to credentialled advanced practice and beyond. Successful implementation is contingent on system-level enablers including organisational commitment, standardised capability frameworks, investment in supervisor development and enabling infrastructure. When these conditions are in place, clinical supervision has the potential to evolve from ad hoc activity into a defining feature of a safe, capable and sustainable advanced pharmacy workforce.</p>