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<p>This correspondence acknowledges the authors’ efforts in addressing an important clinical question and evaluating a practical dosing approach for patients undergoing hemodialysis. We highlight several methodological assumptions within the simulation model that may limit the clinical interpretability of the results, including the extrapolation of PK/PD targets from individuals with normal kidney function, the use of non-standard avibactam thresholds, and the unvalidated implications of prolonged sub-MIC intervals in hemodialysis populations. We further emphasize the need for dedicated PK/PD investigations and supporting clinical outcome data before these dosing strategies can be confidently integrated into practice.</p>

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Comment on “evaluation of high dose post-dialytic versus daily beta-lactam dosing in hemodialysis patients using Monte Carlo simulation”

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月15日

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  • Sarah Alhassan Aljumaa,
  • Mohammed Al Musawa,
  • Rania El Lababidi,
  • Emna Abidi,
  • Islam Ghazi,
  • Wasim S. El Nekidy

摘要

This correspondence acknowledges the authors’ efforts in addressing an important clinical question and evaluating a practical dosing approach for patients undergoing hemodialysis. We highlight several methodological assumptions within the simulation model that may limit the clinical interpretability of the results, including the extrapolation of PK/PD targets from individuals with normal kidney function, the use of non-standard avibactam thresholds, and the unvalidated implications of prolonged sub-MIC intervals in hemodialysis populations. We further emphasize the need for dedicated PK/PD investigations and supporting clinical outcome data before these dosing strategies can be confidently integrated into practice.