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<p>The virus-inhibitory and virucidal properties of semi-synthetic triterpenoids against herpes virus type 1 were studied. The action of the most promising compounds, also active against an acyclovir-resistant strain of herpes virus type 2, betulonic acid amide <b>VIII</b> and 2,3-seco-oleanane ketoester <b>Vh</b>, was studied on a model of cutaneous herpes infection in laboratory animals. The antiherpetic effect of 2% ointment based on ketoester <b>Vh</b> was experimentally shown to be comparable to the action of 5% acyclovir ointment, while the virucidal component played a key role in producing the antiviral effect.</p>

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Inhibitory and Virucidal Properties of Semisynthetic Derivatives of Betulin Against Herpes Simplex Virus

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • G. F. Kraynova,
  • I. A. Tolmacheva,
  • A. V. Konysheva,
  • O. V. Savinova,
  • E. I. Boreko,
  • V. V. Grishko

摘要

The virus-inhibitory and virucidal properties of semi-synthetic triterpenoids against herpes virus type 1 were studied. The action of the most promising compounds, also active against an acyclovir-resistant strain of herpes virus type 2, betulonic acid amide VIII and 2,3-seco-oleanane ketoester Vh, was studied on a model of cutaneous herpes infection in laboratory animals. The antiherpetic effect of 2% ointment based on ketoester Vh was experimentally shown to be comparable to the action of 5% acyclovir ointment, while the virucidal component played a key role in producing the antiviral effect.