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<p>A simple and convenient one-step method for the preparation of new <i>N</i>,<i>N</i>-dialkyl imidazole derivatives exhibiting the properties of room-temperature ionic liquids (RTIL) is proposed. The structures of the obtained compounds were confirmed by IR, PMR spectroscopy, and elemental analysis data. Studies on test samples of <i>Escherichia coli</i> and <i>Aspergillus fumigatus</i> revealed their antibacterial and antifungal properties. The most pronounced antifungal properties were found for 1,3-dioctyl-4-methylimidazolium bromide. Its antifungal effect on the growth of <i>A. fumigatus</i> exceeded the effect of clotrimazole. This compound also had a significant bactericidal effect against <i>E. coli</i>.</p>

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Synthesis and Study of the Antibiotic Properties of New N,N-dialkylated Imidazole Derivatives

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • A. I. Narykina,
  • Z. P. Belousova,
  • N. A. Klenova

摘要

A simple and convenient one-step method for the preparation of new N,N-dialkyl imidazole derivatives exhibiting the properties of room-temperature ionic liquids (RTIL) is proposed. The structures of the obtained compounds were confirmed by IR, PMR spectroscopy, and elemental analysis data. Studies on test samples of Escherichia coli and Aspergillus fumigatus revealed their antibacterial and antifungal properties. The most pronounced antifungal properties were found for 1,3-dioctyl-4-methylimidazolium bromide. Its antifungal effect on the growth of A. fumigatus exceeded the effect of clotrimazole. This compound also had a significant bactericidal effect against E. coli.