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<p>A series of new cyclohexanol derivatives has been synthesized from polyfunctional substituted cyclohexanols and binucleophilic reagents. Some of them have been tested for antibacterial activity against Gram-positive and Gram-negative bacteria. The growth-inhibiting effect of the compounds was independent of structural features of the bacterial membrane and cell wall. A dependence of the antibacterial effect on the compounds on their concentrations was noted.</p>

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Synthesis and Antibacterial Activity of Some New Polyfunctional Derivatives of Cyclohexanols

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • S. L. Kocharov,
  • H. A. Panosyan,
  • M. A. Melkumyan

摘要

A series of new cyclohexanol derivatives has been synthesized from polyfunctional substituted cyclohexanols and binucleophilic reagents. Some of them have been tested for antibacterial activity against Gram-positive and Gram-negative bacteria. The growth-inhibiting effect of the compounds was independent of structural features of the bacterial membrane and cell wall. A dependence of the antibacterial effect on the compounds on their concentrations was noted.