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<p>Previously, cyclic derivatives of phenyl isocyanate and methylphenylene diisocyanate containing 1,3-dioxacycloalkane and <i>gem</i>-dichlorocyclopropane fragments were obtained and characterized. The cytotoxic activity of a series of obtained cyclic derivatives of phenyl isocyanate and methylphenylene diisocyanate was studied <i>in vitro</i> against HCT-116 colon cancer, HepG2 liver cancer, A549 lung cancer, and MCF-7 breast cancer human cell lines. The studied compounds did not exhibit cytotoxic activity towards the studied cell lines and did not increase the proliferation of tumor cells. The antioxidant properties of the compounds were analyzed in an oxidative stress model <i>in vitro</i>. It was shown that some of the studied compounds reduced the viability of all studied tumor cell lines under the conditions of the oxidative stress model.</p>

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Cytotoxic and Antioxidant Activities of New Substituted 1,3-Dioxacycloalkanes and Gem-Dichlorocyclopropanes

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Yu. G. Borisova,
  • D. V. Ishmetova,
  • S. S. Zlotsky,
  • G. Z. Raskil’dina

摘要

Previously, cyclic derivatives of phenyl isocyanate and methylphenylene diisocyanate containing 1,3-dioxacycloalkane and gem-dichlorocyclopropane fragments were obtained and characterized. The cytotoxic activity of a series of obtained cyclic derivatives of phenyl isocyanate and methylphenylene diisocyanate was studied in vitro against HCT-116 colon cancer, HepG2 liver cancer, A549 lung cancer, and MCF-7 breast cancer human cell lines. The studied compounds did not exhibit cytotoxic activity towards the studied cell lines and did not increase the proliferation of tumor cells. The antioxidant properties of the compounds were analyzed in an oxidative stress model in vitro. It was shown that some of the studied compounds reduced the viability of all studied tumor cell lines under the conditions of the oxidative stress model.