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<p>Six new mono organosilicon(IV) complexes of 2-(((2-hydroxynapthalen-1-yl)methylene)amino)acetic acid (LH<sub>2</sub>) <b>(1)</b> derived by the condensation of glycine with 2-hydroxy-1-napthaldehyde were synthesized and characterized by elemental analysis and spectroscopic techniques including infrared, <sup>1</sup>H, <sup>13</sup>C, and <sup>29</sup>Si NMR evidenced the formation of penta-, hexa-, and hepta-coordinated species. New mono organosilicon(IV) complexes CH<sub>3</sub>Si(L)OCH<sub>3</sub> <b>(1a)</b>, CH<sub>3</sub>Si(LH)<sub>2</sub>OCH<sub>3</sub> <b>(1b)</b>, CH<sub>3</sub>Si(LH)<sub>3</sub> <b>(1c)</b>, C<sub>2</sub>H<sub>5</sub>Si(L)OC<sub>2</sub>H<sub>5</sub> <b>(2a)</b>, C<sub>2</sub>H<sub>5</sub>Si(LH)<sub>2</sub>OC<sub>2</sub>H<sub>5</sub> <b>(2b)</b>, and C<sub>2</sub>H<sub>5</sub>Si(LH)<sub>3</sub> <b>(2c)</b> were synthesized by the condensation reaction involving the interaction of corresponding CH<sub>3</sub>Si(OCH<sub>3</sub>)<sub>3</sub> and C<sub>2</sub>H<sub>5</sub>Si(OC<sub>2</sub>H<sub>5</sub>)<sub>3</sub> with 2-(((2-hydroxynapthalen-1-yl)methylene)amino)acetic acid in appropriate stoichiometric molar ratios namely, 1:1, 1:2, and 1:3 in benzene medium. In addition, the ligand and mono organosilicon(IV) complexes were tested for <i>in-vitro</i> antioxidant, anti-denaturation, and anti-diabetic activities. Pharmacological activities of mono organosilicon(IV) complexes increase with an increase in the number of organo groups as well as the coordinating environment of silicon. C<sub>2</sub>H<sub>5</sub>Si(LH)<sub>3</sub> possessed the best antioxidant, anti-denaturation, and anti-diabetic activities.</p>

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Newly Synthesized Complexes of Mono Organosilicon Alkoxides with 2-(((2-Hydroxynapthalen-1-yl)Methylene)-Amino)Acetic Acid: Spectral Characterization, and Pharmacological Activities

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • Sunita Arya,
  • Sonal Verma,
  • Anjana Verma,
  • Robina Aman,
  • Om Prakash

摘要

Six new mono organosilicon(IV) complexes of 2-(((2-hydroxynapthalen-1-yl)methylene)amino)acetic acid (LH2) (1) derived by the condensation of glycine with 2-hydroxy-1-napthaldehyde were synthesized and characterized by elemental analysis and spectroscopic techniques including infrared, 1H, 13C, and 29Si NMR evidenced the formation of penta-, hexa-, and hepta-coordinated species. New mono organosilicon(IV) complexes CH3Si(L)OCH3 (1a), CH3Si(LH)2OCH3 (1b), CH3Si(LH)3 (1c), C2H5Si(L)OC2H5 (2a), C2H5Si(LH)2OC2H5 (2b), and C2H5Si(LH)3 (2c) were synthesized by the condensation reaction involving the interaction of corresponding CH3Si(OCH3)3 and C2H5Si(OC2H5)3 with 2-(((2-hydroxynapthalen-1-yl)methylene)amino)acetic acid in appropriate stoichiometric molar ratios namely, 1:1, 1:2, and 1:3 in benzene medium. In addition, the ligand and mono organosilicon(IV) complexes were tested for in-vitro antioxidant, anti-denaturation, and anti-diabetic activities. Pharmacological activities of mono organosilicon(IV) complexes increase with an increase in the number of organo groups as well as the coordinating environment of silicon. C2H5Si(LH)3 possessed the best antioxidant, anti-denaturation, and anti-diabetic activities.