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<p>The composition and technology of indapamide 1.5 mg extended release mini-tablets were developed as components of a polypill for the treatment of arterial hypertension. Extended release of the active pharmaceutical ingredient (API) was ensured by using a combined matrix-forming agent [hydroxypropyl methylcellulose (HPMC) and sodium carboxymethylcellulose (Na-CMC)]. Selection of the viscosity and concentration of the matrix-forming agent made it possible to obtain a stable hydrogel layer that ensured linear release of indapamide from the mini-tablets throughout a day.</p>

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Development of the Composition and Technology of Antihypertensive Mini-Tablets with Extended Release Based on a Combined Matrix-Forming Agent

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • K. M. Tserkovnaya,
  • E. V. Flisyuk,
  • I. A. Narkevich

摘要

The composition and technology of indapamide 1.5 mg extended release mini-tablets were developed as components of a polypill for the treatment of arterial hypertension. Extended release of the active pharmaceutical ingredient (API) was ensured by using a combined matrix-forming agent [hydroxypropyl methylcellulose (HPMC) and sodium carboxymethylcellulose (Na-CMC)]. Selection of the viscosity and concentration of the matrix-forming agent made it possible to obtain a stable hydrogel layer that ensured linear release of indapamide from the mini-tablets throughout a day.