<p>The acute toxicity and analgesic and anti-inflammatory activity of eight 5-aryl-4-aroyl-1-isobutyl-3-hydroxy-3-pyrrolin-2-ones were studied. It was found that all compounds had low toxicity, demonstrated anti-inflammatory activity, and did not exhibit analgesic action.</p>

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Anti-Inflammatory and Analgesic Activity and Acute Toxicity of 5-aryl-4-aroyl-1-isobutyl-3-hydroxy-3-pyrroline-2-ones

  • V. L. Gein,
  • D. G. Dianova,
  • O. O. Senokosova,
  • E. A. Buldakova,
  • I. P. Rudakova,
  • V. V. Novikova

摘要

The acute toxicity and analgesic and anti-inflammatory activity of eight 5-aryl-4-aroyl-1-isobutyl-3-hydroxy-3-pyrrolin-2-ones were studied. It was found that all compounds had low toxicity, demonstrated anti-inflammatory activity, and did not exhibit analgesic action.