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<p>Effective boron neutron capture therapy (BNCT) requires targeted delivery of as much <sup>10</sup>B as possible to the tumor. Boron-containing nanoparticles (BNPs), in particular, boron-containing quantum dots (BQDs), are promising boron carriers. The affinity of the latter for tumor cells can be achieved by bonding with various biovectors, such as antibodies, specific peptides, etc. To date, bioconjugation methods for BNPs have been developed to a much lesser extent than for chalcogenide QDs. In particular, the use of click-chemistry methods for the preparation of BNP bioconjugates has been little studied. Herein, possible options for using click-chemistry methods for the bioconjugation of functionalized BQDs are considered.</p>

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Functionalization of Boron-Containing Quantum Dots and Prospects for Using Click-Chemistry Methods for Their Covalent Bonding With Biovectors

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • D. V. Krylsky,
  • P. P. Gladyshev,
  • I. S. Korzyutin

摘要

Effective boron neutron capture therapy (BNCT) requires targeted delivery of as much 10B as possible to the tumor. Boron-containing nanoparticles (BNPs), in particular, boron-containing quantum dots (BQDs), are promising boron carriers. The affinity of the latter for tumor cells can be achieved by bonding with various biovectors, such as antibodies, specific peptides, etc. To date, bioconjugation methods for BNPs have been developed to a much lesser extent than for chalcogenide QDs. In particular, the use of click-chemistry methods for the preparation of BNP bioconjugates has been little studied. Herein, possible options for using click-chemistry methods for the bioconjugation of functionalized BQDs are considered.