Scholarlink

<p>The effect of thioctic acid, 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride (emoxipine), and their ester derivative (2-ethyl-6-methylpyridinol-3-yl thioctate; thioxypine) on the behavior of rats in the dark-light chamber test was studied. It was found that a single intraperitoneal injection of thioctic acid, emoxypine, and their equimolar mixture in single doses of 36.25, 72.5, and 145 μmol/kg enhanced the manifestation of anxiety behavior in the dark-light chamber test. Similar proanxiogenic effects were observed when thioctic acid was administered in relatively low doses (36.25 and 72.5 μmol/kg) and emoxypine, in relatively high doses (72.5 and 145 μmol/kg). Equimolar mixing of thioctic acid and emoxypine led to the loss of their proanxiogenic activity in the dark-light chamber test. The combination of thioctic acid and 2-ethyl-6-methyl-3-hydroxypyridine in the structure of the ester thioxypine potentiated their proanxiogenic activity, which manifested as its pronounced anxiogenic effect after a single administration in relatively high doses (72.5 and 145 μmol/kg). Repeated (three-fold) injections of thioxypine caused the development of tolerance to its anxiogenic effect in the dark-light chamber test.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of 2-Ethyl-6-Methylpyridinol-3-yl Thioctate and Its Non-Esterified Components on Anxiety Behavior in Rats in the Dark-Light Chamber Test

  • 期刊论文

  • 发表日期：

    2025年7月31日

查看全文
  • I. A. Volchegorskii,
  • A. I. Sinitskii,
  • S. I. Grobovoi,
  • R. R. Mihajlov,
  • I. Y. Miroshnichenko,
  • L. M. Rassokhina

摘要

The effect of thioctic acid, 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride (emoxipine), and their ester derivative (2-ethyl-6-methylpyridinol-3-yl thioctate; thioxypine) on the behavior of rats in the dark-light chamber test was studied. It was found that a single intraperitoneal injection of thioctic acid, emoxypine, and their equimolar mixture in single doses of 36.25, 72.5, and 145 μmol/kg enhanced the manifestation of anxiety behavior in the dark-light chamber test. Similar proanxiogenic effects were observed when thioctic acid was administered in relatively low doses (36.25 and 72.5 μmol/kg) and emoxypine, in relatively high doses (72.5 and 145 μmol/kg). Equimolar mixing of thioctic acid and emoxypine led to the loss of their proanxiogenic activity in the dark-light chamber test. The combination of thioctic acid and 2-ethyl-6-methyl-3-hydroxypyridine in the structure of the ester thioxypine potentiated their proanxiogenic activity, which manifested as its pronounced anxiogenic effect after a single administration in relatively high doses (72.5 and 145 μmol/kg). Repeated (three-fold) injections of thioxypine caused the development of tolerance to its anxiogenic effect in the dark-light chamber test.