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<p>Four compounds, 20-hydroxyecdysone and three polyacetylenes (polyines), were isolated and identified from rhizomes with roots of <i>Rhaponticum carthamoides</i> (Willd.) Iljin. A significant antiplatelet effect unrelated to the influence on the cyclic nucleotide system was found for one of the polyines, which made it possible to consider it as a potential pharmacological agent for the prevention of thrombosis.</p>

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Isolation of Secondary Metabolites of Rhaponticum carthamoides (Willd.) Iljin and Assessment of Their Antiplatelet Activity

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • N. A. Pronin,
  • A. K. Whaley,
  • A. O. Whaley,
  • S. A. Kuz’mina,
  • N. I. Rukoyatkina,
  • S. P. Gambaryan

摘要

Four compounds, 20-hydroxyecdysone and three polyacetylenes (polyines), were isolated and identified from rhizomes with roots of Rhaponticum carthamoides (Willd.) Iljin. A significant antiplatelet effect unrelated to the influence on the cyclic nucleotide system was found for one of the polyines, which made it possible to consider it as a potential pharmacological agent for the prevention of thrombosis.