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<p>The intention of this study is to synthesize, characterize, and evaluate indoline-2,3-dione-containing Schiff base compounds for their potential antitubercular activity. These synthesized compounds were identified and characterized by using IR, NMR, Mass spectroscopy, and elemental analytical methods. The synthesized compounds were screened for their antimycobacterial activity against <i>Mycobacterium tuberculosis</i> H37Rv via the <i>in-vitro</i> microplate Alamar blue assay (MABA) method. The synthesized compound (<b>2a-e</b>) showed antimycobacterial activity. The result indicated that compounds (<b>2e</b> &amp; <b>2f</b>) had a minimal inhibitory concentration (MIC) value of 12.5 μg/ml. These compounds containing electron-withdrawing groups (Cl &amp; NO<sub>2</sub>) were more active than compounds (<b>2a-d</b>) with an MIC value of 25 μg/ml containing electron-releasing groups (H,OCH<sub>3</sub>, OH, CH<sub>3</sub>). All the compounds exhibited less antimycobacterial activity than the reference drugs (Pyrazinamide – 3.125 μg/ml, Streptomycin – 6.25 μg/ml, and Ciprofloxacin – 3.125 μg/ml).</p>

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Synthesis and In Vitro Antimycobacterial Activity of Some 3-((2-(Arylideneamino)Phenyl)-Imino)Indolin-2-One Derivatives

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Mazen Almehmadi,
  • Abdualziz Alsharif,
  • Osama Abdulaziz,
  • Mohammad Asif

摘要

The intention of this study is to synthesize, characterize, and evaluate indoline-2,3-dione-containing Schiff base compounds for their potential antitubercular activity. These synthesized compounds were identified and characterized by using IR, NMR, Mass spectroscopy, and elemental analytical methods. The synthesized compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv via the in-vitro microplate Alamar blue assay (MABA) method. The synthesized compound (2a-e) showed antimycobacterial activity. The result indicated that compounds (2e & 2f) had a minimal inhibitory concentration (MIC) value of 12.5 μg/ml. These compounds containing electron-withdrawing groups (Cl & NO2) were more active than compounds (2a-d) with an MIC value of 25 μg/ml containing electron-releasing groups (H,OCH3, OH, CH3). All the compounds exhibited less antimycobacterial activity than the reference drugs (Pyrazinamide – 3.125 μg/ml, Streptomycin – 6.25 μg/ml, and Ciprofloxacin – 3.125 μg/ml).