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<p>The aim of the research was to study the transcutaneous diffusion kinetics of desloratadine from two types of matrix patches containing the active substance in ionic and nanostructured forms (in the form of micelles based on Tween-80). The study included an assessment of the efficiency of desloratadine transport through a cellulose membrane and through rat skin using Franz diffusion cells. Desloratadine and patch components were quantitatively determined using UV spectrometry. The results showed that matrix patches containing desloratadine in micellar form provided a more complete and prolonged release of the active substance in experiments with rat skin, which confirmed their potential for use as an effective form of transcutaneous delivery of this drug.</p>

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Transcutaneous Diffusion Kinetics of Desloratadine from Matrix Patches

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • V. P. Ageev,
  • A. V. Zaborovskiy,
  • L. A. Tararina,
  • D. V. Yunina,
  • A. K. Fomenko,
  • D. V. Kurkin,
  • A. E. Pyanzina,
  • V. I. Shlyapkina,
  • I. A. Gololobova,
  • O. A. Kulikov,
  • N. A. Pyataev

摘要

The aim of the research was to study the transcutaneous diffusion kinetics of desloratadine from two types of matrix patches containing the active substance in ionic and nanostructured forms (in the form of micelles based on Tween-80). The study included an assessment of the efficiency of desloratadine transport through a cellulose membrane and through rat skin using Franz diffusion cells. Desloratadine and patch components were quantitatively determined using UV spectrometry. The results showed that matrix patches containing desloratadine in micellar form provided a more complete and prolonged release of the active substance in experiments with rat skin, which confirmed their potential for use as an effective form of transcutaneous delivery of this drug.