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<p>The effects of solvent and crystallization conditions on the formation of various polymorphic modifications of cabozantinib-(<i>S</i>)-malate were studied using powder x-ray diffraction. A new polymorphic modification of cabozantinib-(<i>S</i>)-malate was isolated and identified using x-ray phase analysis. The results obtained in the work may be useful in technology development for manufacturing active pharmaceutical ingredients</p>

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Crystallization Conditions of Polymorphic Forms of Cabozantinib-(S)-Malate

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • A. A. Zemtsov,
  • A. A. Kurohtin,
  • P. S. Chizhov,
  • N. L. Babak,
  • A. R. Shaikhutdinova,
  • I. O. Konstantinov,
  • Yu. D. Afanas’ev,
  • A. Yu. Alasheev

摘要

The effects of solvent and crystallization conditions on the formation of various polymorphic modifications of cabozantinib-(S)-malate were studied using powder x-ray diffraction. A new polymorphic modification of cabozantinib-(S)-malate was isolated and identified using x-ray phase analysis. The results obtained in the work may be useful in technology development for manufacturing active pharmaceutical ingredients