Scholarlink

<p>To synthesize hydroxycamptothecin-loaded ã-PGA-PAE nanoparticles to improve the therapeutic efficacy of 10-hydroxycamptothecin (HCPT) against the tumors. Nanoparticles were evaluated for <i>in vitro</i> anticancer activity and induction of apoptosis against LoVo human colon cancer cells. The results showed that HCPT/PGA-PAE nanoparticles (HCPT-NPs), with a particle size of 187.5 nm and a PDI of 0.278, were successfully prepared with a relatively uniform size distribution and a good dispersibility. The drug release profile of HCPT-NPs <i>in vitro</i> was sustained-release, with pH having an effect. Compared to ã-PGA-PAE nanomaterials or free HCPT, HCPT-NPs exhibited higher inhibiting colon cell growth performance <i>in vitro</i>. These results suggest that HCPT-loaded nanoparticles represent a new approach for improved delivery of anticancer drugs and therapeutic efficacy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preparation of Hydroxycamptothecin-Loaded Nanoparticles with Enhanced Antiproliferative Effect on LoVo Human Colon Cancer Cells

  • 期刊论文

  • 发表日期：

    2025年3月1日

查看全文
  • Jinjian Jin,
  • Hao Guo,
  • Chuangang Zang,
  • Jianhua Liu,
  • Yumei Wang,
  • Jijuan Zhang,
  • Shan Ren,
  • Dan Liu,
  • Songjie Fan

摘要

To synthesize hydroxycamptothecin-loaded ã-PGA-PAE nanoparticles to improve the therapeutic efficacy of 10-hydroxycamptothecin (HCPT) against the tumors. Nanoparticles were evaluated for in vitro anticancer activity and induction of apoptosis against LoVo human colon cancer cells. The results showed that HCPT/PGA-PAE nanoparticles (HCPT-NPs), with a particle size of 187.5 nm and a PDI of 0.278, were successfully prepared with a relatively uniform size distribution and a good dispersibility. The drug release profile of HCPT-NPs in vitro was sustained-release, with pH having an effect. Compared to ã-PGA-PAE nanomaterials or free HCPT, HCPT-NPs exhibited higher inhibiting colon cell growth performance in vitro. These results suggest that HCPT-loaded nanoparticles represent a new approach for improved delivery of anticancer drugs and therapeutic efficacy.