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<p>Seven compounds were studied in this work: three sodium salts of pyrrolo[3,4-<i>c</i>]pyrazol-3-ones (<b>Ia-c</b>) and four silver salts of pyrrolo[3,4-<i>c</i>]pyrazol-3-ones (<b>IIa-d</b>). Compound <b>Ia</b> was found to enhance the spontaneous and stimulated production of reactive oxygen species by peritoneal leukocytes. Compound <b>Ic</b> also had an activating effect on stimulated luminol-dependent chemiluminescence (LDCL). An assessment of the effect of sodium salts of pyrrolopyrazoles on phagocytosis activity showed a stimulating effect of <b>Ia</b> on the percentage of phagocytosis of peritoneal leukocytes. Silver salts of pyrrolopyrazoles had an opposite effect on the dynamics of the oxidative burst and phagocytic activity. Compound <b>IId</b> was found significantly to inhibit both spontaneous and simulated production of oxygen radicals. In addition, compounds <b>IIa</b> and <b>IIc</b> had a less pronounced inhibitory effect on stimulated LDCL. Compound <b>IId</b> statistically significantly reduced the percentage of phagocytosis of peritoneal phagocytes.</p>

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Influence of Sodium and Silver Salts of Pyrrolopyrazoles on Innate Immunity Reactions In Vivo

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • S. V. Gein,
  • O. V. Bobrovskaya,
  • E. A. Makarov,
  • V. L. Gein

摘要

Seven compounds were studied in this work: three sodium salts of pyrrolo[3,4-c]pyrazol-3-ones (Ia-c) and four silver salts of pyrrolo[3,4-c]pyrazol-3-ones (IIa-d). Compound Ia was found to enhance the spontaneous and stimulated production of reactive oxygen species by peritoneal leukocytes. Compound Ic also had an activating effect on stimulated luminol-dependent chemiluminescence (LDCL). An assessment of the effect of sodium salts of pyrrolopyrazoles on phagocytosis activity showed a stimulating effect of Ia on the percentage of phagocytosis of peritoneal leukocytes. Silver salts of pyrrolopyrazoles had an opposite effect on the dynamics of the oxidative burst and phagocytic activity. Compound IId was found significantly to inhibit both spontaneous and simulated production of oxygen radicals. In addition, compounds IIa and IIc had a less pronounced inhibitory effect on stimulated LDCL. Compound IId statistically significantly reduced the percentage of phagocytosis of peritoneal phagocytes.