Scholarlink

<p>5-Arylthio-2-(4-hydroxyphenyl)-1,3,4-oxadiazole derivatives (<b>3a-e</b>) were synthesized and screened for their <i>in-vitro</i> antimicrobial activities. The title compounds were synthesized from the following reactions—the reaction of ethyl 4-hydroxybenzoate with hydrazine hydrate formed 4-hydroxybenzohydrazide (<b>1</b>), and 4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol (<b>2</b>) formed by condensation reaction between compound <b>1</b> and carbon disulfide. Compound <b>2</b> reacted with different aromatic halides to produce the title compounds. Spectral analysis techniques, including IR, <sup>1</sup>H NMR, and mass spectroscopy, were used to analyze all of the title compounds. By using the filter paper disc technique, the title compounds’ <i>in-vitro</i> antibacterial activity was evaluated against Gram-positive (<i>B. subtilis, S. aureus</i>), and Gram-negative (<i>E. coli, P. aeruginosa</i>) microorganisms. Also, via this technique, the <i>in-vitro</i> antifungal activity was evaluated against <i>Candida albicans</i>. All of the substances exhibited strong antibacterial activity against the examined bacterial and fungal strains.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and In-Vitro Screening of 5-Arylthio-2-(4-Hydroxyphenyl)-1,3,4-Oxadiazole Derivatives as Potential Antimicrobial Agents

  • 期刊论文

  • 发表日期：

    2025年1月1日

查看全文
  • Mazen Almehmadi,
  • Mamdouh Allahyani,
  • Abdulelah Aljuaid,
  • Osama Abdulaziz,
  • Mohammad Asif

摘要

5-Arylthio-2-(4-hydroxyphenyl)-1,3,4-oxadiazole derivatives (3a-e) were synthesized and screened for their in-vitro antimicrobial activities. The title compounds were synthesized from the following reactions—the reaction of ethyl 4-hydroxybenzoate with hydrazine hydrate formed 4-hydroxybenzohydrazide (1), and 4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol (2) formed by condensation reaction between compound 1 and carbon disulfide. Compound 2 reacted with different aromatic halides to produce the title compounds. Spectral analysis techniques, including IR, 1H NMR, and mass spectroscopy, were used to analyze all of the title compounds. By using the filter paper disc technique, the title compounds’ in-vitro antibacterial activity was evaluated against Gram-positive (B. subtilis, S. aureus), and Gram-negative (E. coli, P. aeruginosa) microorganisms. Also, via this technique, the in-vitro antifungal activity was evaluated against Candida albicans. All of the substances exhibited strong antibacterial activity against the examined bacterial and fungal strains.