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<p>An on-chip multi-trench waveguide-based biosensor is designed to detect a broad range of refractive indices (RI) across diverse biological and biochemical samples. The biosensor is designed to operate on the principle that variations in RI produce a measurable shift in wavelength. Upon contact with the sensing surface, changes in the analyte’s RI alter its optical properties, leading to a wavelength shift. The design consists of a TeO<sub>2</sub> core with multi-trenches on both sides of the core region, fabricated on a sapphire substrate. The results indicate that the reported waveguide-based biosensor exhibits a high sensitivity, i.e., 1000&#xa0;nm/RIU, and a low detection limit of 0.025 RIU, for the RI range 1.30–1.40.</p>

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Design and analysis of a multi-trench waveguide-based biosensor for improved sensitivity in different analytes detection

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Sushmita Nain,
  • Than Singh Saini

摘要

An on-chip multi-trench waveguide-based biosensor is designed to detect a broad range of refractive indices (RI) across diverse biological and biochemical samples. The biosensor is designed to operate on the principle that variations in RI produce a measurable shift in wavelength. Upon contact with the sensing surface, changes in the analyte’s RI alter its optical properties, leading to a wavelength shift. The design consists of a TeO2 core with multi-trenches on both sides of the core region, fabricated on a sapphire substrate. The results indicate that the reported waveguide-based biosensor exhibits a high sensitivity, i.e., 1000 nm/RIU, and a low detection limit of 0.025 RIU, for the RI range 1.30–1.40.