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<p>Breast cancer cells 4T1 cells exhibit a negative surface charge characteristic to most cancer cells due to the movement of mobile ions across the cell membrane. They are effectively damaged by photodynamic action using polycationic photosensitizers. Photosensitizers based on long-wavelength polycationic phthalocyanines demonstrate stability of their optical properties on a wide range of concentrations, high in vitro phototoxicity in the nanomole range due high extinction and quantum yield of reactive oxygen species, as well as effective binding of polycationic PS molecules to the surface of tumor cells. The studied PSs proved to be very effective for photodynamic therapy against breast cancer cells 4T1 and exhibited complete photodestruction of the cells at nanomolar concentrations.</p>

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Photophysical properties of photosensitizers based on polycationic phthalocyanines and their phototoxicity against breast cancer cells

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • Ekaterina V. Akhlyustina,
  • Igor D. Romanishkin,
  • Irina G. Meerovich,
  • Dmitry A. Bunin,
  • Aleksey S. Skobeltsin,
  • Svetlana V. Monich,
  • Maria P. Stepanova,
  • Alexander G. Martynov,
  • Victor B. Loschenov,
  • Yi-Jia Yan,
  • Zhi-Long Chen,
  • Gennady A. Meerovich,
  • Yulia G. Gorbunova,
  • Igor V. Reshetov

摘要

Breast cancer cells 4T1 cells exhibit a negative surface charge characteristic to most cancer cells due to the movement of mobile ions across the cell membrane. They are effectively damaged by photodynamic action using polycationic photosensitizers. Photosensitizers based on long-wavelength polycationic phthalocyanines demonstrate stability of their optical properties on a wide range of concentrations, high in vitro phototoxicity in the nanomole range due high extinction and quantum yield of reactive oxygen species, as well as effective binding of polycationic PS molecules to the surface of tumor cells. The studied PSs proved to be very effective for photodynamic therapy against breast cancer cells 4T1 and exhibited complete photodestruction of the cells at nanomolar concentrations.