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<p>Despite advances in terahertz metamaterial sensors, most designs remain limited by narrow functionality, complex fabrication and restricted sensitivity for biomedical diagnostics. This study presents a cost-effective terahertz metasurface biosensor engineered for high-sensitivity multi-disease detection. The device integrates four concentric octagonal resonators fabricated in aluminum on a low-loss polyimide spacer backed by a metallic ground plane, achieving three distinct resonance peaks. Optimization yielded sensitivity exceeding 1.18 THz/RIU and quality factors above 13, with complete polarization insensitivity and angular stability up to 60°. The sensor demonstrates reliable detection of hemoglobin level variations associated with anemia and other blood disorders, a diverse array of pesticide residues and organic solvents and bacterial contaminants such as Escherichia coli and Pseudomonas aeruginosa. Its sensitivity and stability further support potential applications in monitoring metabolic conditions such as diabetes, detecting infectious agents and screening environmental pollutants. Consistent resonance responses across all tested analytes shows the design’s effectiveness for rapid, noninvasive analysis. This versatile approach holds promise for high-end sensing in clinical diagnostics, food safety and environmental surveillance.</p>

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Multispectral terahertz metasurface biosensor supporting multi-disease identification and chemical sensing

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Taha Sheheryar,
  • Xin Dong,
  • Xuening Wang,
  • Bo Lv,
  • Lei Gao,
  • Baodong Xie

摘要

Despite advances in terahertz metamaterial sensors, most designs remain limited by narrow functionality, complex fabrication and restricted sensitivity for biomedical diagnostics. This study presents a cost-effective terahertz metasurface biosensor engineered for high-sensitivity multi-disease detection. The device integrates four concentric octagonal resonators fabricated in aluminum on a low-loss polyimide spacer backed by a metallic ground plane, achieving three distinct resonance peaks. Optimization yielded sensitivity exceeding 1.18 THz/RIU and quality factors above 13, with complete polarization insensitivity and angular stability up to 60°. The sensor demonstrates reliable detection of hemoglobin level variations associated with anemia and other blood disorders, a diverse array of pesticide residues and organic solvents and bacterial contaminants such as Escherichia coli and Pseudomonas aeruginosa. Its sensitivity and stability further support potential applications in monitoring metabolic conditions such as diabetes, detecting infectious agents and screening environmental pollutants. Consistent resonance responses across all tested analytes shows the design’s effectiveness for rapid, noninvasive analysis. This versatile approach holds promise for high-end sensing in clinical diagnostics, food safety and environmental surveillance.