<p>This paper presents a novel design of a multiband biosensor based on metamaterial for the detection of early-stage cancer. The proposed biosensor consists of a square ring, a circular slot inside the square patch, and eight circular sector patch resonators designed by gold material printed on the top layer of polyimide dielectric substrate, exhibiting resonance peaks at 0.4267 THz, 0.9514 THz, 1.4365 THz, and 2.832 THz with absorption values 99%, 97.8%, 98.8%, and 97.9% respectively. Additionally, the proposed absorber is identified as being insensitive to polarization and is capable of handling wide-angle incidence effectively up to 80°. The resonant frequency of the proposed absorber is sensitive to the variation of the analyte’s refractive index loaded on the proposed absorber’s top surface. The effect of the analyte’s varying thickness and refractive index is studied to find the optimum sample thickness. In addition, the maximum sensitivity, figure of merit (FOM), and quality factor for 1:2 were 257.5&#xa0;GHz/RIU, 4.2 RIU^− 1, 17.6 respectively. Thereafter, the performance of the proposed absorber is applied to biomed samples to detect various forms of cancer, viz. breast, skin, stomach, and cervical, at early stages. The presented results demonstrate that the proposed biosensor has the ability for early-stage cancer detection.</p>