<p>Spiral waves are a core dynamic mechanism behind various malignant arrhythmias, and the evolution of their spatial positions directly determines the overall pattern of myocardial electrical activity. Elimination methods that directly disrupt the spiral wave structure by strongly blocking ion channels often require high doses and are accompanied by significant side effects. This paper proposes a method for inducing spiral wave drift based on subthreshold ion channel modulation. In the MV and Luo–Rudy myocardial models, by applying spatial gradient blocking to different ion channels, we found that ion channel gradients can induce sustained and clearly directional drift of spiral waves without destroying their stable rotating structure. We further investigated the mechanism of spiral wave drift and found that, regardless of the type of ion channel gradient blocking, the spiral wave consistently drifts toward regions with a larger period. Based on these results, we propose that the rotation period of spiral wave can serve as a unified and effective physical indicator for predicting and regulating the direction of spiral wave drift. This paper provides new theoretical basis for developing low-dose and fewer side effect antiarrhythmic intervention strategies.</p>