<p>Actuator fault and hysteresis input are critical and challenging in mechatronic systems. This paper considers fault-tolerant control for an uncertain non-affine system with predefined performance in the presence of actuator fault and input hysteresis. A novel estimation scheme, based on extended state observers, is proposed for nonlinear terms and residuals resulting from input hysteresis and actuator fault. A hyperbolic tangent function is embedded in an event-triggered scheme to address the issue of triggered jumps caused by faults. A tracking differentiator-based filter is used to overcome design conflicts between the event-triggered control signal and the input hysteresis. It is proven that all signals are ultimately bounded, and the tracking error converges to a tunable residual around the origin. Two examples, including a numerical simulation and a piezo-positioning mechanic system, are given to illustrate the effectiveness of the event-triggered fault-tolerant control scheme.</p>